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Touma Kamijou is a student living in Academy City, a highly advanced place in terms of technology. Despite being gauged as a level zero esper (no powers), he possesses on his right hand the Imagine Breaker, an ability that negates any power whatsoever. Touma finds a young girl named Index who is trying to run away from Necessarius, a powerful magic organization that she is member of. Blessed with the skill of memorizing any sort of information, she holds 103,000 forbidden magical books within her head. As science and magic cross paths, Touma must face several dangers amid espers and magicians who appear in the exciting scientific town.

Academy City pulses with advanced technology and supernatural espers, yet the most dangerous variable is a powerless student with a hand that negates all miracles. This collision of science and magic creates a chaotic landscape where even a zero-level outsider can upend the status quo.

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