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On a flight from Los Angeles to Paris, a mad scientist on the run from the CIA is transporting a coffin containing the body of a colleague infected with a genetically modified virus. While the 747 crosses a violent thunderstorm, the instability of the aircraft allows the corpse to get out of its container.

Claustrophobic tension builds as a mid-air storm turns a commercial cabin into a pressurized tomb. Once the genetically modified corpse escapes its coffin, the flight transforms into a frantic struggle for survival against an airborne nightmare.

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