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You can stream Galaxy Express 999 (1978) on Crunchyroll with a subscription.

In a distant future, Tetsuro is a human boy who wants his body replaced with a robotic one. This is possible, but to do so he has to reach the Immortal Planet onboard the space train Galaxy Express 999. Maetel, a beautiful and mysterious blonde woman dressed in Russian style, joins him in the long journey through space. Every episode sees our heroes arriving in a new planet's space train station.

Melancholy echoes through the lonely, star-strewn corridors of a locomotive hurtling toward eternity. This cosmic odyssey pairs a desperate boy with a mysterious blonde guide to question the heavy cost of immortality.