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The story takes place in an age where "Ajin" (demi-human), more casually known as "Demi," have slowly started to become accepted into human society. Tetsuo Takahashi is a biology teacher who ends up teaching three such Demi, hoping to understand more about them while also managing to catch their attention.

A biology teacher attempts to bridge the gap between species by educating three distinct demi-humans in his classroom. This slice-of-life comedy finds humor in the awkward social friction and biological quirks of a world where monsters finally belong.

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