Karakuri Circus

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You can stream Karakuri Circus (2018) on Amazon Prime with a subscription.

Narumi Katou is a middle-aged man who suffers from the bizarre ZONAPHA Syndrome: a rare and inexplicable disease that causes its victims to endure severe seizures at random, with the only cure being to watch someone laugh. One day, during Narumi's part time job, a young boy with a giant suitcase fleeing from three adults runs into him. The boy introduces himself as Masaru Saiga, the new owner of the famous Saiga Enterprises following his father's recent death. However, other members of his family are trying to assassinate him and claim the fortune for themselves.

A man plagued by a bizarre syndrome that demands laughter to prevent deadly seizures finds himself thrust into a chaotic chase. This surreal journey begins when a boy with a mysterious suitcase becomes the target of a relentless pursuit.